Globalization has multiplied security challenges and significantly reduced the gap between domestic and international security. Security threats that develop within a domestic context can quickly escalate to have an impact beyond borders. Besides, the line between traditional and non-traditional threats to security has become increasingly blurred. New and complex security issues including pandemics, migration, energy security, cyber warfare, and climate change present decision-makers with challenges that need quick and efficient responses. In this context, good governance becomes a key issue. The first annual meeting of the Global Think Tank Security Forum held in Venice, Italy discussed some of the major security challenges facing nations today and provided an overview from regional and transnational perspectives. This volume contains the papers that were presented at the meeting.